Entropy Neurodynamics Completes Cohort 1 Dosing Ahead of July 2026 Data
Entropy Neurodynamics has completed first-cohort dosing in its Entropy Neurodynamics TRP-8803 BED Trial, with all six participants achieving controlled and reproducible psychedelic responses ahead of July 2026 topline efficacy data.
Key Takeaways
- All six Cohort 1 participants in the TRP-8803 Phase 2 study achieved controlled and reproducible psychedelic responses across two administrations delivered 14 days apart.
- The IV-infused psilocin platform demonstrated high-intensity responses across all patients, validating the drug delivery mechanism ahead of efficacy readouts.
- Topline Cohort 1 efficacy results are expected in July 2026, representing the next major catalyst for investors tracking the programme.
- Cohort 2 recruitment is 83% complete with five of six participants enrolled, and dosing will commence following Data Safety and Monitoring Board review of Cohort 1 safety data.
- Entropy's prior Phase 2a oral psilocybin programme in BED, combined with a 75% response rate in the TRP-8802 IBS trial, provides a strong clinical foundation for the TRP-8803 development programme.
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