Actinogen Medical XanaMIA Alzheimer’s Trial Clears Key DMC Review to Final Results

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Key Takeaways

Actinogen Medical receives positive DMC recommendation to continue XanaMIA Alzheimer's trial without amendment after independent review of unblinded efficacy data, validating trial integrity ahead of pivotal November 2026 results.

  • Positive DMC recommendation after reviewing real efficacy data validates trial integrity and reduces binary risk ahead of November 2026 results
  • Xanamem's novel cortisol-targeting mechanism and oral once-daily dosing differentiate it from current injectable Alzheimer's treatments
  • FDA alignment provides clear regulatory pathway with second pivotal trial planned for 2027
  • Open-label extension starting March 2026 will generate valuable long-term safety and efficacy data for regulatory submissions
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