Cyclopharm’s Technegas Named Preferred Agent in Landmark US Clinical Guideline

Technegas named preferred ventilation agent in landmark US clinical guideline

Cyclopharm (ASX: CYC) has received significant recognition for its flagship product, with peak US nuclear medicine bodies releasing a draft clinical guideline explicitly naming Technegas as the preferred ventilation agent for lung imaging. The multinational guideline states “for most conditions, including the assessment of pulmonary embolism, technetium agents are typically used, with Technegas generally preferred when available.” This represents the first comprehensive update to US-aligned lung imaging guidance since 2012, positioning the guideline as a material catalyst for institutional adoption across America’s hospital network.

The draft Procedure Standard and Guideline for Ventilation-Perfusion (V/Q) Pulmonary Scintigraphy has been developed through collaboration between the US Society of Nuclear Medicine and Molecular Imaging (SNMMI), the American College of Nuclear Medicine (ACNM), the European Association of Nuclear Medicine (EANM), and experts from Australia and Canada. The guideline features Technegas in its introduction as a clinical advancement “which has enhanced the diagnostic accuracy and clinical utility of lung scintigraphy”. Following public consultation currently underway, final publication is expected within coming months.

Why clinical guidelines drive hospital procurement and reimbursement

Clinical practice guidelines serve as evidence-based frameworks that shape how healthcare professionals diagnose and treat medical conditions. Unlike individual research studies, guidelines synthesise peer-reviewed data with expert consensus to establish standards of care. Multi-society international collaborations carry exceptional authority because they represent alignment across diverse clinical perspectives and regulatory environments.

These documents influence healthcare delivery through three primary mechanisms:

1. Clinical practice standardisation: Guidelines establish benchmarks for appropriate care, directing clinicians toward evidence-supported treatment approaches.
2. Hospital procurement decisions: Formulary committees reference guidelines when evaluating new technologies and making purchasing decisions for their institutions.
3. Insurance reimbursement policies: Coverage determinations by insurers frequently align with guideline-endorsed interventions, as these represent accepted standards of care.

For Cyclopharm (ASX: CYC), guideline recognition removes a critical barrier to institutional adoption. Hospital systems seeking to modernise their nuclear medicine capabilities can now reference authoritative guidance explicitly naming Technegas as the preferred agent, streamlining internal approval processes and supporting capital expenditure justifications.

What the draft guideline says about Technegas

Preferred agent status

The guideline’s positioning of Technegas extends beyond mere acknowledgment. The document explicitly states “for most conditions, including the assessment of pulmonary embolism, technetium agents are typically used, with Technegas generally preferred when available.”

This preferred agent designation places Technegas at the forefront of clinical consideration for ventilation imaging across US healthcare institutions. The guideline underwent what developers describe as a “thorough clinical consensus process and extensive review” before public release, indicating robust vetting of its recommendations.

The 12-year gap since the last comprehensive US guidance update positions Technegas within a modernised clinical framework that reflects contemporary imaging technology and expanded diagnostic applications. The guideline references advanced imaging techniques including artificial intelligence alongside functional ventilation agents like Technegas, integrating the product into cutting-edge nuclear medicine practice.

Expanded clinical applications recognised

Beyond traditional pulmonary embolism diagnosis, the draft guideline acknowledges the expanding clinical utility of SPECT and SPECT/CT imaging with Technegas across multiple disease states and interventional applications:

• Chronic thromboembolic pulmonary hypertension
• COPD
• Asthma
• Post-PE follow-up
• Lung transplantation
• Radiotherapy planning
• Regional lung function assessment

This multi-indication recognition significantly expands Technegas’ addressable market opportunity. Rather than positioning the product solely within acute diagnostic pathways for suspected blood clots, the guideline validates its use across chronic disease management, surgical planning, and therapeutic monitoring. Each additional indication represents incremental revenue potential per installed site as clinicians integrate Technegas into broader clinical workflows.

Accelerating Technegas adoption across US healthcare

US clinical guidance recognition represents a material inflection point for market penetration in the world’s largest healthcare economy. Clinical guidelines create durable changes in institutional behaviour because they establish reference standards that persist across physician turnover, technology upgrades, and evolving reimbursement landscapes.

CEO James McBrayer emphasised the unique authority carried by multi-society international guidelines:

“Guidelines developed through international multi-society collaboration are uncommon and carry a unique level of authority within clinical practice. When such consensus guidelines are established, they represent a foundational reference point for clinicians and institutions. When combined with peer-reviewed clinical evidence, these guidelines sit at the top of the hierarchy of evidence required to enable durable changes in clinical behaviour, hospital procurement and reimbursement decisions.”

The company expects the guideline’s inclusion and positioning of Technegas will drive accelerated clinical demand across US hospitals and health systems. Preferred agent status supports broader institutional adoption, increased utilisation rates, and more rapid integration into standard clinical protocols.

The public consultation process allows the global nuclear medicine community to provide feedback before final publication, though the guideline has already undergone extensive internal review. This suggests the core recommendations, including Technegas’ preferred status, are unlikely to change materially.

What guideline recognition means for Cyclopharm’s US growth trajectory

The draft guideline positions Cyclopharm (ASX: CYC) to capture meaningful market share within America’s healthcare system. Three investment implications stand out:

1. Preferred agent differentiation: Explicit guideline recognition distinguishes Technegas from alternative ventilation imaging methods, providing sales teams with authoritative clinical support.
2. Institutional adoption catalyst: Hospital systems can now reference multi-society international consensus when evaluating Technegas, accelerating procurement cycles and reducing internal resistance to technology adoption.
3. Expanded revenue per site: Multi-indication recognition extends beyond traditional pulmonary embolism diagnosis into chronic disease management and interventional applications, increasing utilisation potential at each installed location.

The 12-year gap since previous US guidance positions this update as a generational shift in lung imaging standards. By featuring Technegas alongside contemporary technologies like artificial intelligence and advanced SPECT/CT imaging, the guideline integrates the product into modern nuclear medicine practice rather than legacy diagnostic frameworks.

CEO commentary underscores the hierarchical importance of multi-society consensus documents. When peer-reviewed clinical evidence combines with international guideline endorsement, the resulting framework sits at the apex of evidence standards referenced by hospital formulary committees, clinical departments, and insurance reimbursement bodies. This creates compounding adoption momentum as each institutional approval reinforces Technegas’ position as standard of care.

For investors, the draft guideline removes a critical de-risking question around US market penetration. Clinical acceptance, regulatory approval, and now authoritative guideline recognition align to support Cyclopharm’s growth thesis in its largest addressable market. Final publication in coming months will cement Technegas’ preferred status within the formal clinical reference framework guiding US nuclear medicine practice.

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